The goal of this article is to explain how the criteria were created and define the 3 categories of indications: appropriate, inappropriate, and uncertain. Tips for using appropriate use criteria and tables, including a definition of several key terms technologists should be familiar with, will be provided. Journal of Nuclear Medicine Technology June 2012, 40 (2) 81-86; DOI: https://doi.org/10.2967/jnmt.111.097451